Neuromas are enlarged benign growths of nerves, most commonly between the third and fourth toes. They are caused by tissue rubbing against and irritating the nerves. Pressure from poorly-fitting shoes or abnormal bone structure can create the condition as well. Treatments include special shoes or inserts and/or cortisone injections, but surgical removal of the growth is sometimes necessary.

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| Excessive training, such as running long distances without rest, places repeated stress on the foot and ankle. The result can be stress fractures and muscle/tendon strains. |
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